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Systems radiobiology approach to the investigation of radiotherapy effectiveness at blocking NRF2 antioxidant system of cancer cellsстатья Тезисы
- Авторы: Golyshev G.G., Goltsov A.N.
- Сборник: Международная научная конференция «Инновационные технологии ядерной медицины и лучевой диагностики и терапии», Международная молодежная школа «Инновационные ядерно-физические методы высокотехнологичной медицины»
- Год издания: 2023
- Первая страница: 58
- Последняя страница: 59
- Аннотация: In this work, we developed a computational method in systems radiobiology to investigate effectiveness of RT in combination with targeted therapy which directs at the inhibition of NRF2 antioxidant system of cancer cells. NRF2 transcriptional factor is a key element of the defense cellular system which is activated under oxidative stress in cells induced in part by ionizing radiation (IR). Its activation triggered by the increasing reactive oxygen species (ROS) in cells leads to the expression of a large number of antioxidant enzymes which neutralize ROS and protect DNA from damage. We assumed that suppression of the NRF2 antioxidant system in cancer cells enhances radiosensitivity of the cells due to the increasing damage of cancer cell DNA by ROS generated by water radiolysis at IR
- Добавил в систему: Гольцов Алексей Николаевич