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Two-in-One Sensor of Refractive Index and Raman Scattering using Hollow−Core Microstructured Optical Waveguides for Colloid Characterizationстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Merdalimova Anastasiia, Barmin Roman, Vorobev Viktor, Aleksandrov Artem, Terentyeva Daria, Estifeeva Tatiana, Chernyshev Vasiliy, German Sergey, Maslov Oleg, Skibina Yulia, Rudakovskaya Polina, Gorin Dmitry
- Журнал: Colloids and Surfaces B: Biointerfaces
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 113705
- DOI: 10.1016/j.colsurfb.2023.113705
- Аннотация: Hollow−core microstructured optical waveguides (HC−MOW) have recently emerged in sensing technologies, including the gas and liquid detection for industrial as well as clinical applications. Antiresonant HC−MOW provide capabilities for applications in refractive index (RI) sensing, while the long optical path for analyte−light interaction in HC−MOW leads to increased sensitivity of sensor based on Raman scattering signal measurements. In this study, we developed a two−in−one sensor device using HC−MOW for RI and Raman scattering detection. The performance of the sensor was evaluated by characterizing protein−copolymer multicomponent colloids, specifically, bovine serum albumin (BSA) and poly(N−vinyl−2−pyrrolidone−co−acrylic acid) P(VP−AA) nano−sized complexes and microbubbles of the corresponding shell. Monocomponent solutions showed linear dependencies of RI and characteristic Raman peak intensities on mass concentration. Multicomponent Raman sensing of BSA@P(VP−AA) complexes and microbubbles revealed that changes in P(VP−AA) characteristic peak intensities can describe interactions between components needed to produce colloid systems. RI sensing of multicomponent colloids demonstrated linear dependence on total mass concentrations for BSA@P(VP−AA) complexes, while corresponding BSA@P(VP−AA) microbubbles can be detected with concentrations as high as 4.0 × 10^8 MB/mL. Therefore, the developed two−in−one sensor of RI and Raman scattering can be used the robust characterization of albumin−based colloids designed for therapeutic and diagnostic needs.
- Добавил в систему: Александров Артем Игоревич