Liposomal form of 2-alkylthioimidazolone-based copper complexes for combined cancer therapy

Авторы: Iakimova Tamara M., Bubley Anna A., Boychenko Olga P., Guk Dmitry A., Vaneev Alexander N., Prusov Andrey N., Erofeev Alexander S., Gorelkin Petr V., Krasnovskaya Olga O., Klyachko Natalia L., Vlasova Kseniia Yu
Журнал: Nanomedicine
Год издания: 2023
Издательство: Future Medicine Ltd.
Местоположение издательства: United Kingdom
Первая страница: 1
Последняя страница: 19
DOI: 10.2217/nnm-2023-0210
Аннотация: This work introduces a new technique for copper-containing drugs encapsulation in a drug-delivery system. The drug, a promising copper compound, is embedded in lipid nanovesicles – tiny fat particles – for intravenous injection. In addition to chemical characterization of the obtained drug form, tests on cancer cells showed a noticeable effect, whereas healthy cell types were not harmed. Copper possesses not only anticancer effects but also antimicrobial properties, which are also shown by the drug form, and a test of combined suppression of cancer cell lines and bacteria was successful. Hence, the obtained drug form has the potential for dual treatment of cancer and bacterial infections.
Добавил в систему: Клячко Наталья Львовна

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