|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Pseudo Four-Component Synthesis of 5,6-Dihydroindolo[2,1-<i>a</i>]isoquinolinesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Miftyakhova Almira R., Borisova Tatiana N., Fakhrutdinov Artem N., Ilyushenkova Valentina V., Titov Alexander A., Efimov Ilya V., Tafeenko Victor A., Varlamov Alexey V., Voskressensky Leonid G.
- Журнал: Journal of Organic Chemistry
- Год издания: 2024
- Издательство: American Chemical Society
- Местоположение издательства: United States
- DOI: 10.1021/acs.joc.3c02133
- Аннотация: AbstractAbstract ImageAn easy synthesis of novel highly functionalized 5,6-dihydroindolo[2,1-a]isoquinolines was developed via a pseudo four-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal α,β-ynones, and malononitrile. The selective formation of this biologically relevant heterocyclic core was achieved using a one-pot approach under microwave irradiation. The formation of the same skeleton through the reaction of 5,6-dihydropyrrolo[2,1-a]isoquinolines with malonic acid dinitrile supports the proposed mechanism, involving the intermediate product of the three-component reaction. Furthermore, the disproval of an alternative reaction pathway, which involved the dimerization of malononitrile followed by three-component transformation, was demonstrated. Introducing the malononitrile dimer as a CH acid resulted in the formation of a different pyrido[3′,4′:4,5]pyrrolo[2,1-a]isoquinoline core. Additionally, the synthesized 5,6-dihydroindolo[2,1-a]isoquinolines were examined for their photophysical properties, revealing their attractive luminescent characteristics.
- Добавил в систему: Тафеенко Виктор Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Результаты экспериментов | jo3c02133_si_001_gXPTxC8.pdf | 8,7 МБ | 6 января 2024 [Tafeenko] | |
| 2. | Полный текст | miftyakhova-et-al-2024-pseudo-four-component-synthesis-of-5… | 2,7 МБ | 19 января 2024 [Tafeenko] | |
| 3. | Результаты экспериментов | jo3c02133_si_001.pdf | 8,7 МБ | 6 января 2024 [Tafeenko] |