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The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforteстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 января 2024 г.
- Авторы: Mishin D.V., Isaeva E.I., Grigorian S.S., Balakina A.A., Ilyichev A.V., Deryabin P.G., Maldov D.G.
- Журнал: Biology Bulletin
- Том: 47
- Номер: 5
- Год издания: 2020
- Издательство: M A I K Nauka - Interperiodica
- Местоположение издательства: Russian Federation
- Первая страница: 448
- Последняя страница: 454
- DOI: 10.1134/s1062359020050076
- Аннотация: The effect of the drug Stimforte on infection by the Hepatitis C virus (HCV) has been studied. Stimforte partially inhibits HCV infection at a dose of 100 μg/mouse and almost completely at a dose of 300 μg/mouse within 24 h after administration of the drug. The mice sera resulting after 24 h in the presence of 100 and 300 µg/mouse of Stimforte effectively inhibit the production of HCV. Doses of 150, 200, and 250 µg/mouse are not effective. Stimulation of interferon-β (IFN-β) production is only observed at doses of 100 and 300 µg/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-γ also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-λ. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups.
- Добавил в систему: Ильичёв Александр Владимирович