|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Evaluation of the anionic effect on the formation of biologically active {CuII-phenx; x = 1, 2, 3} fragments - Synthetic and structural variations, antimycobacterial and antiblastoma effectsстатья Исследовательская статья
Дата последнего поиска статьи во внешних источниках: 25 января 2024 г.
- Авторы: Koshenskova Kseniya A., Baravikov Dmitrii E., Kayukova Lyudmila A., Ergalieva Elmira M., Nelyubina Yulia V., Nikiforova Marina E., Dolgushin Fedor M., Fedin Matvey V., Bekker Olga B., Shender Victoria O., Malyants Irina K., Aliev Teimur M., Titov Konstantin O., Eremenko Igor L., Lutsenko Irina A.
- Журнал: Polyhedron
- Год издания: 2024
- Издательство: Pergamon Press
- Местоположение издательства: United States
- Номер статьи: 116852
- DOI: 10.1016/j.poly.2024.116852
- Аннотация: Two cationic and molecular copper(II) complexes - mixed ligand[{Cu(phen)2benz}{Cu(phen)2Cl}]2+·2Cl-·benz-·H3O+·4.5H2O (1), [Cu(benz)2phen] (2) (benz- =m-Cl-benzoate anion; phen = 1,10-phenantroline) and [Cu(phen)3]2+·2OTf-·2EtOH (3) (OTf =trifluoromethylsulfonate, triflate anion, CF3SO3-) were synthesized using various syntheticapproaches and thoroughly characterized by spectroscopic methods and single crystal X-raydiffraction analysis. The structures of the complexes according to X-ray diffraction data arecharacterized by a diverse geometric environment of the complexing agent - the cationic form of1 comprises two structurally nonequivalent moieties: the Cu (1) and Cu (2) complex-formingatoms coordinate, in chelate manner, two phen moieties each and the benz- (1) / Сl- (2) anions,respectively, thus forming different-ligand formula units, a trigonal-bipyramidal {Cu(1)N4Cl} anda pseudo octahedral one {Cu(2)N4O2}. The copper(II) ion in the complex 2 coordinates one phenligand in a bidentate mode and two benz- anions to produce a distorted planar square environment{CuN2O2}. In complex 3, the copper(II) cation is surrounded by three phenanthroline fragments{Cu(phen)3}2+ and non-coordinated OTf- ions. The results of an EPR study 1 show that in the solidphase, intermolecular exchange interactions that cause exchange narrowing of the spectrum areefficient, whereas in solutions, resolved spectra of copper(II) ion with rhombic symmetry of theg-tensor are observed. An in vitro study of the biological properties of 1-3 toward nonpathogenicmycobacterial strain Mycolicibacterium smegmatis showed an increase in biological effectivenessdepending on the structure of complexes (MIC, 1 (2 nmol/disk) > 3 (5 nmol/disk) > 2 (12.5nmol/disk)). Complex 1 was also tested for antitumor activity against an ovarian adenocarcinomaSKOV3 demonstrated high efficiency: the IC50 value is almost 9 times higher than the activity ofсisplatin.Keywords: copper(II) complexes, 1,10-phenantroline, crystal structure, EPR, antiblastomaactivity, non-pathogenic strain.
- Добавил в систему: Титов Константин Олегович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Экспертное заключение | ekspertnoe_zaklyuchenie.pdf | 405,7 КБ | 5 февраля 2024 [maiki1508] | |
| 2. | Полный текст | 1-s2.0-S0277538724000287-main.pdf | 2,2 МБ | 25 января 2024 [maiki1508] | |
| 3. | Первая страница | Screenshot_8.png | 144,9 КБ | 25 января 2024 [maiki1508] | |
| 4. | Screenshot_1.png | Screenshot_1.png | 122,2 КБ | 25 января 2024 [maiki1508] | |
| 5. | Screenshot_8_i0VXeY2.png | Screenshot_8_i0VXeY2.png | 144,9 КБ | 25 января 2024 [maiki1508] |