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Impact of homeostatic body hydration status, evaluated by hemodynamic measures, on different pain sensitization paths to a chronic pain syndromeстатья Исследовательская статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 апреля 2024 г.
- Авторы: Davydov Dmitry M., de la Coba Pablo, Contreras-Merino Ana M., Reyes del Paso Gustavo A.
- Журнал: Scientific reports
- Том: 14
- Номер: 1
- Год издания: 2024
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Номер статьи: 1908
- DOI: 10.1038/s41598-024-52419-3
- Аннотация: Contrasting findings on the mechanisms of chronic pain and hypertension development render the current conventional evidence of a negative relationship between blood pressure (BP) and pain severity insufficient for developing personalized treatments. In this interdisciplinary study, patients with fibromyalgia (FM) exhibiting clinically normal or elevated BP, alongside healthy participants were assessed. Different pain sensitization responses were evaluated using a dynamic ’slowly repeated evoked pain’ (SREP) measure, as well as static pain pressure threshold and tolerance measures. Cardiovascular responses to clino‑orthostatic (lying‑standing) challenges were also examined as acute re‑ and de‑hydration events, challenging cardiovascular and cerebrovascular homeostasis. These challenges involve compensating effects from various cardiac preload or afterload mechanisms associated with different homeostatic body hydration statuses. Additionally, hair cortisol concentration was considered as a factor with an impact on chronic hydration statuses. Pain windup(SREP) and lower pain threshold in FM patients were found to be related to BP rise during clinostatic(lying) rehydration or orthostatic (standing) dehydration events, respectively. These events were determined by acute systemic vasoconstriction (i.e., cardiac afterload response) overcompensating for clinostatic or orthostatic cardiac preload under‑responses (low cardiac output or stroke volume).Lower pain tolerance was associated with tonic blood pressure reduction, determined by permanent hypovolemia (low stroke volume) decompensated by permanent systemic vasodilation. In conclusion,the body hydration status profiles assessed by (re)activity of systemic vascular resistance and effective blood volume‑related measures can help predict the risk and intensity of different pain sensitization components in chronic pain syndrome, facilitating a more personalized management approach.
- Добавил в систему: Давыдов Дмитрий Михайлович