Glycyrrhizinic acid and phosphatidylcholine combination as a preventive therapy for experimental murine non-alcoholic steatohepatitis

Prikhodko, V.A.; Matuzok, T.M.; Karev, V.E.; Karavaeva, A.V.; Spasenkova, O.M.; Kirillova, N.V.; Ivkin, D.Y.; Okovityi, S.V.

Авторы: Prikhodko V.A., Matuzok T.M., Karev V.E., Karavaeva A.V., Spasenkova O.M., Kirillova N.V., Ivkin D.Yu, Okovityi S.V.
Журнал: Livers
Том: 4
Номер: 1
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 63
Последняя страница: 83
DOI: 10.3390/livers4010006
Аннотация: Non-alcoholic metabolic-associated steatohepatitis (MASH) is a condition characterized by increasingly high prevalence and incidence, and also represents an important unmet medical need when it comes to effective pharmacotherapy. In this work, we aimed to explore the therapeutic possibilities of the synergistic combined use of glycyrrhizinic acid (GA) and phosphatidylcholine (PC) to prevent experimental MASH. Adult C57Bl/6 mice were used to model dietary/toxic MASH and treated orally by either GA (34.3 mg/kg/d) or a GA + PC combination (34.3 + 158.1 mg/kg/d) for 3 months. Animal locomotion, behaviour, short-term memory, physical performance, neuromuscular joint function, blood biochemistry, and oxidative stress marker levels were evaluated, followed by histological examination of the liver, skeletal muscle and sciatic nerve with tissue ammonia and lipid content determination. Real-time polymerase chain reaction was used to measure the relative expression of several pathogenetic transcript markers. GA and PC showed moderate additive synergism in their anti-inflammatory, antioxidant, hypoammonaemic, hypoglycaemic, and procognitive activities. Differential effects of the agents were seen in regard to anxiety- and depressionlike behaviour as well as gene expression. Our results indicate partial pharmacological synergism between GA and PC and validate further research of its potential clinical applications.
Добавил в систему: Оковитый Сергей Владимирович

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Glycyrrhizinic acid and phosphatidylcholine combination as a preventive therapy for experimental murine non-alcoholic steatohepatitisстатья

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