Аннотация:Structural changes of the brain in schizophrenia progress over time and their extent differs depending on the patient, yet their mechanisms remain unclear. Polymorphisms in the genes regulating immune response and inflammation have associations with the risk of schizophrenia. Studying their impact on the structural parameters of the brain in the patients is relevant for prediction of cognitive impairment. The goal of this work was to investigate the possible associations of polymorphisms of IL10 immonoregulatory gene with neuroanatomic changes in schizophrenia to gain new insights on the role of immunogenetic factors in the development of neurodegeneration in the patients. 89 patients and 99 healthy volunteers were enrolled. SNPs of IL10 gene (G-1082A and C-592A) were determined by polymerase chain reaction. MRI scans were performed on a Siemens Magnetom Verio 3T MRI scanner. It was found that the A allele for G-1082A SNP and CC genotype for C-592A SNP are more frequent in the patients than in the control group, and are significantly (p < 0.01) associated with decreased mean thickness in a number of areas of the frontal cortex in the patients. These findings are important for revealing the role of immunogenetic factors regulating IL-10 production in the pathogenesis of neurodegeneration in schizophrenia. Further research directed at finding and confirming new immunogenetic markers of structural brain changes in schizophrenia is important for identifying the various biological variants of the disease that can differ in pathogenesis, clinical presentation and therapeutic opportunities.Malashenkova, I.K. et al. (2024). Polymorphisms of IL10 Immunoregulatory Gene Impact the Morphometric Changes of the Brain in Schizophrenia. In: Samsonovich, A.V., Liu, T. (eds) Biologically Inspired Cognitive Architectures 2023. BICA 2023. Studies in Computational Intelligence, vol 1130. Springer, Cham. https://doi.org/10.1007/978-3-031-50381-8_61