|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Perinatal hypoxia weakens anticontractile influence of NO in rat arteries during early postnatal periodстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Shvetsova Anastasia A., Khukhareva Daria D., Simonenko Sofia D., Khlystova Margarita A., Borzykh Anna A., Gaynullina Dina K.
- Журнал: Pediatric Research
- Год издания: 2024
- Издательство: Lippincott Williams & Wilkins Ltd.
- Местоположение издательства: United States
- DOI: 10.1038/s41390-024-03062-1
- Аннотация: BACKGROUND: Perinatal hypoxia affects a lot of neonates worldwide every year, however its effects on the functioning of systemiccirculation are not clear yet. We aimed at investigation the effects of perinatal hypoxia on the second day of life on the functioningof the rat systemic vasculature in early postnatal period.METHODS: 2-day-old male rat pups were exposed to normobaric hypoxia (8% O2, 92% N2) for 2 hours. At the 11-14 days cutaneous(saphenous) arteries were isolated and studied by wire myography and Western blotting.RESULTS: Hypoxia weakened the contribution of anticontractile influence of NO, but did not affect the contribution of Rho-kinaseor Kv7 channels to the contraction to α1-adrenergic agonist methoxamine. The content of eNOS and protein kinase G were notaltered by hypoxic conditions.CONCLUSION: Perinatal hypoxia in rats at the second day of life leads to the decrease of anticontractile effect of NO in the systemicarteries in early postnatal ontogenesis (at the age of 11-14 days). Decreased anticontractile effect of NO can be the reason forinsufficient blood supply and represent a risk factor for the development of cardiovascular disorders.
- Добавил в систему: Швецова Анастасия Алексеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|