Gut Microbiota and Biomarkers of Endothelial Dysfunction in Cirrhosis

Efremova, I.; Maslennikov, R.; Poluektova, E.; Medvedev, O.; Kudryavtseva, A.; Krasnov, G.; Fedorova, M.; Romanikhin, F.; Bakhitov, V.; Aliev, S.; Sedova, N.; Kuropatkina, T.; Ivanova, A.; Zharkova, M.; Pervushova, E.; Ivashkin, V.

Авторы: Efremova Irina, Maslennikov Roman, Poluektova Elena, Medvedev Oleg, Kudryavtseva Anna, Krasnov George, Fedorova Maria, Romanikhin Filipp, Bakhitov Vyacheslav, Aliev Salekh, Sedova Natalia, Kuropatkina Tatiana, Ivanova Anastasia, Zharkova Maria, Pervushova Ekaterina, Ivashkin Vladimir
Журнал: International Journal of Molecular Sciences
Том: 25
Номер: 4
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 1988
DOI: 10.3390/ijms25041988
Аннотация: Our aim was to study the association of endothelial dysfunction biomarkers with cirrhosis manifestations, bacterial translocation, and gut microbiota taxa. The fecal microbiome was assessed using 16S rRNA gene sequencing. Plasma levels of nitrite, big endothelin-1, asymmetric dimethylarginine (ADMA), presepsin, and claudin were measured as biomarkers of endothelial dysfunction, bacterial translocation, and intestinal barrier dysfunction. An echocardiography with simultaneous determination of blood pressure and heart rate was performed to evaluate hemodynamic parameters. Presepsin, claudin 3, nitrite, and ADMA levels were higher in cirrhosis patients than in controls. Elevated nitrite levels were associated with high levels of presepsin and claudin 3, the development of hemodynamic circulation, hypoalbuminemia, grade 2–3 ascites, overt hepatic encephalopathy, high mean pulmonary artery pressure, increased abundance of Proteobacteria and Erysipelatoclostridium, and decreased abundance of Oscillospiraceae, Subdoligranulum, Rikenellaceae, Acidaminococcaceae, Christensenellaceae, and Anaerovoracaceae. Elevated ADMA levels were associated with higher Child–Pugh scores, lower serum sodium levels, hypoalbuminemia, grade 2–3 ascites, milder esophageal varices, overt hepatic encephalopathy, lower mean pulmonary artery pressure, and low abundance of Erysipelotrichia and Erysipelatoclostridiaceae. High big endothelin-1 levels were associated with high levels of presepsin and sodium, low levels of fibrinogen and cholesterol, hypocoagulation, increased Bilophila and Coprobacillus abundances, and decreased Alloprevotella abundance.
Добавил в систему: Медведев Олег Стефанович

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Gut Microbiota and Biomarkers of Endothelial Dysfunction in Cirrhosisстатья

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