|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
The aqueous extract of Ulomoides dermestoides larvae counteract motor and cognitive disfunction in a neurotoxic model of Parkinson's diseaseстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Ambaryan Alexander V., Kovalzon Vladimir M., Ushakova Nina A.
- Журнал: Neuroscience and Behavioral Physiology
- Том: 53
- Номер: 5
- Год издания: 2023
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 752
- Последняя страница: 762
- DOI: 10.1007/s11055-023-01463-z
- Аннотация: Insects are a potential source of novel bioactive compounds with pharmaceutical applications. Our previousstudy revealed the presence of antioxidant system proteins in the aqueous extract of Ulomoides dermestoidesFairmaire 1893 larvae, which exhibited high antioxidant activity in vitro and improved cognitive and motorfunctions in aging mice. To determine whether the extract of Ulomoides dermestoides larvae can enhancemotor control and cognitive performance in a neurotoxic model of the initial stage of Parkinson’s disease,adult male C57Bl/6 mice (n = 10/group) were injected intraperitoneally with paraquat neurotoxin, whichpenetrates the blood–brain barrier and causes oxidative stress that destroys dopaminergic neurons of thesubstantia nigra (more detail about protocol treatment and motor and cognitive impairments typical for themice model of PD can be found in our previous publication – Kovalzon et al. [19]. Two groups, E0.2 andE0.4, received either 0.2 or 0.4 mg/kg of daily oral doses of the aqueous extract of Ulomoides dermestoideslarvae, respectively, for 1 week before and during neurotoxin administration. The effects were comparedto neurotoxin-only (Ctox) and intact control (Cin) groups. Motor coordination and cognitive performancewere assessed using the Rotarod, vertical pole, and object recognition tests. Neurotoxin administrationsignificantly impaired motor and cognitive functions in Ctox. The E0.4 but not E0.2 treatment significantlyattenuated the behavioral effects of the neurotoxin (up to the 90% of Cin values). Oral administration of theaqueous extract of Ulomoides dermestoides larvae can significantly counteract the impairments of motorskills and cognitive performance induced by the neurotoxic model of Parkinson’s disease. The neuroprotective effect is likely to reflect the earlier established antioxidant properties of the extract.
- Добавил в систему: Ковальзон Владимир Матвеевич