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MAGNETIC NANOPARTICLE DEGRADATION IN VIVO STUDIED BY MöSSBAUER SPECTROSCOPY В сборникестатья
- Авторы: Nikitin M., Deyev S., Gabbasov R., Cherepanov V., Chuev M., Polikarpov M., Panchenko V.
- Сборник: AIP Conference Proceedings. Сер. "8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
- Год издания: 2010
- Первая страница: 401
- Последняя страница: 407
- DOI: 10.1063/1.3530046
- Аннотация: Magnetic nanoparticles belong to the most promising nanosized objects for biomedical applications. However, little is known about clearance of magnetic nanoparticles from the organism. In this work superparamagnetic iron oxide particles fluidMAG-ARA were injected into tail vein of mice at a dose of 17 mg per 20 g body weight. At various time intervals after the injection the mice were sacrificed and their organs collected. A Mössbauer study allowed to detect magnetic particles in the liver and spleen and showed the degradation of the particles with incorporation of exogenous iron into paramagnetic ferritin-like iron species.
- Добавил в систему: Панченко Владислав Яковлевич