The Role of Changes in Structure and Dynamics of Chromatin due to COVID-19статья
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Дата последнего поиска статьи во внешних источниках: 10 апреля 2024 г.
Аннотация:The COVID-19 pandemic has become a serious challenge for the healthcare system and the econ- omy of many states, and understanding the molecular mechanisms of the pathogenesis of this disease has become a significant challenge for modern science. At the same time, for the first time, a number of high- precision and high-throughput methods for analyzing molecular processes were available to scientists, including technologies for studying changes in chromatin at the genomic level. In this review, we discuss var- ious modern methods that have been used or can be used to study changes in the structure and dynamics of chromatin during infection with SARS-CoV-2 and present the results of currently available studies on the role of these changes in the pathogenesis of COVID-19, and in conclusion, we review the currently known molec- ular mechanisms of chromatin modulation that occur during infection with SARS-CoV-2.