Molecular weight of polyanion affects the biological activity of interpolycomplexesстатья
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Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
Аннотация:Cationic poly(diallyldimethylammonium chloride) formsnonstoichiometric positively charged interpolyelectrolytecomplexes (IPECs) with short- and long-chain anionicsodium polyacrylate. When added to anionic liposomes, theshort-chain polyanion IPECs dissociate and the freepolycation binds to the liposomes, whereas the long-chainpolyanion IPECs bind to the liposomes as a whole. Theseresults correlate with the antimicrobial activity of IPECs,thereby highlighting the important role of polymer molecularweight in the cellular response to IPEC binding.