The Functions of N6-Methyladenosine in Nuclear RNAsстатья
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Дата последнего поиска статьи во внешних источниках: 10 апреля 2024 г.
Аннотация:N6-methyladenosine (m6A) is one of the most common modifications in both eukaryotic and prokaryotic
mRNAs. It has been experimentally confirmed that m6A methylation is involved in the regulation of stability and
translation of various mRNAs. Until recently, the majority of m6A-related studies have been focused on the cytoplasmic functions of this modification. Here, we review new data on the role of m6A in several key biological processes taking place in the cell nucleus, such as transcription, chromatin organization, splicing, nuclear-cytoplasmic
transport, and R-loop metabolism. Based on analysis of these data, we suggest that m6A methylation of nuclear
RNAs is another level of gene expression regulation which, together with DNA methylation and histone modifications, controls chromatin structure and functioning in various biological contexts.