Direct Determination of the Structure of Single Biopolymer Molecules Using Nanopore Sequencingстатья
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Дата последнего поиска статьи во внешних источниках: 10 апреля 2024 г.
Аннотация:This review highlights operational principles, features, and modern aspects of the developmentof third-generation sequencing technology of biopolymers focusing on the nucleic acids analysis, namely thenanopore sequencing system. Basics of the method and technical solutions used for its realization are considered,from the first works showing the possibility of creation of these systems to the easy-to-handle proceduredeveloped by Oxford Nanopore Technologies company. Moreover, this review focuses on applications, which weredeveloped and realized using equipment developed by the Oxford Nanopore Technologies, including assemblyof whole genomes, methagenomics, direct analysis of the presence of modified bases.