Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Eshboev, F.; Mamadalieva, N.; Nazarov, P.A.; Hussain, H.; Katanaev, V.; Egamberdieva, D.; Azimova, S.

Авторы: Eshboev F., Mamadalieva N., Nazarov P.A., Hussain H., Katanaev V., Egamberdieva D., Azimova S.
Журнал: Antibiotics
Том: 13
Год издания: 2024
Издательство: MDPI Publishing
Местоположение издательства: Basel, Switzerland, Switzerland
Первая страница: 1
Последняя страница: 36
Номер статьи: 271
DOI: 10.3390/antibiotics13030271
Аннотация: Infectious diseases are a significant challenge to global healthcare, especially in the face ofincreasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophyticmicroorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to producediverse bioactive compounds with substantial pharmacological potential. Therefore, numerous newantimicrobial compounds have been isolated from endophytes, particularly from endophytic fungiand actinomycetes. However, only a limited number of these compounds have been subjected tocomprehensive studies regarding their mechanisms of action against bacterial cells. Furthermore, theinvestigation of their effects on antibiotic-resistant bacteria and the identification of biosynthetic geneclusters responsible for synthesizing these secondary metabolites have been conducted for only a subset of these promising compounds. Through a comprehensive analysis of current research findings,this review describes the mechanisms of action of antimicrobial drugs and secondary metabolitesisolated from endophytes, antibacterial activities of the natural compounds derived from endophytesagainst antibiotic-resistant bacteria, and biosynthetic gene clusters of endophytic fungi responsiblefor the synthesis of bioactive secondary metabolites.
Добавил в систему: Назаров Павел Александрович

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Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganismsстатья

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