What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins

Авторы: Saidova A.A., Vorobjev I.A.
Журнал: Molecular Biology
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
DOI: 10.1134/s002689332470002x
Аннотация: The functions of actin and its motor proteins myosins in the cytoplasm have been the subject ofresearch for more than 100 years, but the existence and function of these proteins in the nucleus has been amatter of debate until recently. Recent data has clarified the role of actin and myosin molecules in controllingthe dynamics of processes in the cell nucleus, chromatin organization and genome integrity. New microscopytechniques and the use of modified actin-binding probes have made it possible for the first time to directlyvisualize the polymerization of actin filaments in the nucleus of living cells. Here we discuss the processes thatcontrol the dynamic balance of actin and myosins between the nucleus and the cytoplasm, as well as the roleof these proteins in the regulation of transcription, DNA repair, chromatin reorganization, tumor transformation and cell differentiation
Добавил в систему: Саидова Алина Александровна

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