Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties

Zykova, M.V.; Bratishko, K.A.; Buyko, E.E.; Azarkina, L.A.; Ivanov, V.V.; Mihalyov, D.A.; Trofimova, E.S.; Danilets, M.G.; Ligacheva, A.A.; Konstantinov, A.I.; Ufandeev, A.A.; Rabtsevich, E.S.; Drygunova, L.A.; Zima, A.P.; Bashirov, S.R.; Udut, E.V.; Belousov, M.V.

Авторы: Zykova Maria V., Bratishko Kristina A., Buyko Evgeny E., Azarkina Lyudmila A., Ivanov Vladimir V., Mihalyov Dmitrii A., Trofimova Evgeniya S., Danilets Marina G., Ligacheva Anastasia A., Konstantinov Andrey I., Ufandeev Alexander A., Rabtsevich Evgenia S., Drygunova Larisa A., Zima Anastasia P., Bashirov Sergey R., Udut Elena V., Belousov Mikhail V.
Журнал: Molecules
Том: 29
Номер: 7
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1530
Последняя страница: 1530
DOI: 10.3390/molecules29071530
Аннотация: An investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds. An assessment was performed for the chemical, microbiological, and pharmacological safety parameters, as well as the biological efficacy. The HS sample meets the safety requirements in microbiological purity, toxic metals content (lead, cadmium, mercury, arsenic), and radionuclides. The presence of 11 essential elements was determined. The absence of general, systemic toxicity, cytotoxicity, and allergenic properties was demonstrated. The coal HS sample was classified as a Class V hazard (low danger substances). High antioxidant and antiradical activities and immunotropic and cytoprotective properties were identified. The ability of the HS to inhibit hydroxyl radicals and superoxide anion radicals was revealed. Pronounced actoprotective and nootropic activities were also demonstrated in vivo. Intragastric administration of the HS sample resulted in the improvement of physical parameters in mice as assessed by the “swim exhaustion” test. Furthermore, intragastric administration in mice with cholinergic dysfunction led to a higher ability of animals with scopolamine-induced amnesia to form conditioned reflexes. These findings suggest that the studied HS sample is a safe and effective natural substance, making it suitable for use as a dietary bioactive supplement.
Добавил в систему: Константинов Андрей Иванович

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Propertiesстатья

Прикрепленные файлы