|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Regulation of 5-oxo-ETE synthesis by nitric oxide in human polymorphonuclear leukocytes upon their interaction with zymosan and Salmonella typhimuriumстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 сентября 2014 г.
- Авторы: Viryasova GM, Galkina SI, Gaponova TV, Romanova JM, Sud'ina GF
- Журнал: Bioscience Reports
- Том: 34
- Номер: 3
- Год издания: 2014
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 207
- Последняя страница: 216
- DOI: 10.1042/BSR20130136
- Аннотация: Here, we have presented data on the regulation of leukotriene and 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) syntheses in human neutrophils upon interaction with opsonized zymosan (OZ) or Salmonella typhimurium. Priming of neutrophils with PMA and LPS elicits 5-oxo-ETE formation in neutrophils exposed to OZ, and the addition of arachidonic acid significantly increases 5-oxo-ETE synthesis. We found that nitric oxide-releasing compounds induce 5-oxo-ETE synthesis in neutrophils treated with OZ or Salmonella typhimurium. Exposure of neutrophils to zymosan or bacteria in the presence of the NO donor 1,1-diethyl-2-hydroxy-2-nitroso-hydrazine sodium considerably increased the conversion of endogenously formed 5-HETE to 5-oxo-ETE. To our knowledge, this study is the first to demonstrate that nitric oxide is a potent regulator of 5-oxo-ETE synthesis in human polymorphonuclear leukocytes exposed to Salmonella typhimurium and zymosan.
- Добавил в систему: Судьина Галина Федоровна