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Two Types of Survival Curves of Different Lines of Progeric Miceстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 мая 2024 г.
- Авторы: Sokolov Svyatoslav S., Severin Fedor F.
- Журнал: Biochemistry (Moscow)
- Том: 89
- Номер: 2
- Год издания: 2024
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 367
- Последняя страница: 370
- DOI: 10.1134/s0006297924020147
- Аннотация: For most of their lifespan, the probability of death for many animal species increases with age. Gompertz law states that this increase is exponential. In this work, we have compared previously published data on the sur- vival kinetics of different lines of progeric mice. Visual analysis showed that in six lines of these rapidly aging mu- tants, the probability of death did not strictly depend on age. In contrast, ten lines of progeric mice have survival curves similar to those of the control animals, that is, in agreement with Gompertz law, similar to the shape of an exponential curve upside down. Interestingly, these ten mutations cause completely different cell malfunctions. We speculate that what these mutations have in common is a reduction in the lifespan of cells and/or an acceler- ation of the transition to the state of cell senescence. Thus, our analysis, similar to the conclusions of many previ- ously published works, indicates that the aging of an organism is a consequence of the aging of individual cells.
- Добавил в систему: Соколов Святослав Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | BCM0367_Sokolov.pdf | 245,4 КБ | 15 мая 2024 [SokolSS] |