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OXIDATIVE DAMAGE OF DNA, PROTEINS AND C-REACTIVE PROTEIN PARAMETERS IN GIRLS AND BOYS WITH EXOGENOUS CONSTITUTIONAL OBESITYстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 июня 2024 г.
- Авторы: Darenskaya M.A., Rychkova L.V., Kolesnikov S.I., Semenova N.V., Nikitina O.A., Lesnaya A.S., Kolesnikova L.I.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 176
- Номер: 3
- Год издания: 2024
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 328
- Последняя страница: 331
- DOI: 10.1007/s10517-024-06018-x
- Аннотация: The parameters of oxidative damage of DNA, proteins, as well as the parameters of the thiol-disulfide system and C-reactive protein in adolescent girls and boys with exogenous constitutional obesity (ECO) were evaluated. In girls and boys with obesity, the levels of 8-hydroxy-2’-deoxyguanosine (marker of DNA destruction) were higher than in controls. Evaluation of the activity of the thiol-disulfide system revealed increased levels of oxidized glutathione (GSSG) and decreased levels of the reduced glutathione (GSH) and GSSG ratio (GSH/GSSG) in adolescents with ECO regardless of the sex in comparison with the control. C-reactive protein was also higher in the ECO groups regardless of the sex. The levels of glutathione peroxidase in obese boys were higher than in girls. In view of the revealed shifts, corrective measures with the prescription of drugs with antioxidant properties are recommended in adolescents with ECO to stabilize the indices.
- Добавил в систему: Колесников Сергей Иванович