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Behavioral effect of dipeptide NGF mimetic GK-2 in an in vivo model of rat traumatic brain injury and its neuroprotective and regenerative properties in vitroстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 августа 2015 г.
- Авторы: Stelmashook EV, Genrikhs EE, Novikova SV, Barskov IV, Gudasheva TA, Seredenin SB, Khaspekov LG, Isaev NK
- Журнал: International Journal of Neuroscience
- Том: 125
- Номер: 5
- Год издания: 2015
- Издательство: Taylor & Francis
- Местоположение издательства: United Kingdom
- Первая страница: 375
- Последняя страница: 379
- DOI: 10.3109/00207454.2014.935376
- Аннотация: A protective behavioral effect of a nerve growth factor dipeptide mimetic GK-2 in the model of open focal trauma of rat brain sensorimotor cortex and its antioxidative and regenerative properties in cultures of rat cerebellar granule cells and mouse embryonal spinal ganglion, respectively, were studied. Intraperitoneal injections of GK-2 (1 mg/kg) for 5 days daily after traumatic brain injury improved significantly motor function of limbs. Moreover, supplementation the incubation medium with GK-2 (0.5-1.5 mg/l) decreased neuronal death induced by H2O2 in cerebellar granule cell cultures and stimulated neurite outgrowth from cultured mouse embryonal spinal ganglia. Our results suggest that GK-2 exhibits pronounced positive behavioral effect in vivo as well as neuroprotective and regenerative effects in vitro, and that these neuroprotective properties probably associated with cell survival but not with cell differentiation pathway.
- Добавил в систему: Исаев Николай Константинович