Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics

Авторы: Kurmaz Svetlana V., Ulyanov Ivan V., Emelyanova Nina S., Kurmaz Vladimir A., Kozlov Alexey V., Sizov Lev R., Rybkin Alexander Yu
Журнал: Mendeleev Communications
Том: 34
Номер: 4
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 492
Последняя страница: 495
DOI: 10.1016/j.mencom.2024.06.007
Аннотация: Water-soluble nanosized systems of aluminum phthalocyanine (PcAlCl) as promising photosensitizer for photodynamic therapy and fluorescent diagnostics have been developed by its encapsulation into biocompatible copolymers of N-vinylpyrrolidone with (di)methacrylates. Physicochemical (water solubility, stability, nanoparticle size) and photophysical (absorption, fluorescence) properties of the obtained nanoparticles in an aqueous solution were studied. According to quantum chemical modeling, coordination bonds are formed between the Al atom of the dye and the oxygen atoms of all monomer units.
Добавил в систему: Курмаз Владимир Александрович

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