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Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillationsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 июля 2024 г.
- Авторы: Pavlovsky Philip, Sayfulina Ksenia, Gamaleya Anna, Tomskiy Alexey, Belova Elena, Sedov Alexey
- Журнал: Clinical Neurophysiology
- Том: 165
- Год издания: 2024
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 36
- Последняя страница: 43
- DOI: 10.1016/j.clinph.2024.06.003
- Аннотация: AbstractObjectiveWe aimed to establish specific biomarkers of Parkinson’s disease (PD) by comparing activity of more affected (MA) and less affected (LA) subthalamic nucleus (STN) of patients with prominent clinical asymmetry.MethodsWe recorded single unit activity and local field potentials (LFP) of the STN during deep brain stimulation surgeries. Neuronal firing patterns and discharge rate, as well as oscillatory features of both single cells and LFP, were analyzed.ResultsWe observed notable differences in proportions of irregular-burst and pause-burst, but not tonic neurons, between the hemispheres. Oscillations of pause-burst neurons correlated significantly with the bradykinesia and rigidity scores of the corresponding hemibody. LFP derived from MA STN featured greater power in 12–15 Hz.ConclusionsOur results provide evidence that the increased proportion of units with prolonged pauses may be associated with PD. We also speculate that some of them may gain rhythmicity in the alpha-beta range in relation to hypokinetic symptoms, long-term disease, or both.SignificanceOur findings highlight the relation between specific oscillatory features of the STN, predominance of subthalamic pause-burst units and PD pathophysiology.KeywordsSTNParkinson’s diseaseClinical asymmetryMicroelectrode registrationLocal field potential
- Добавил в систему: Гамалея Анна Александровна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 1-s2.0-S1388245724001767-main.pdf | 1,1 МБ | 30 июня 2024 [agamaleya_nsi] |