Oscillatory subthalamic cell motor responses are associated with clinical characteristics of Parkinson’s disease

Nezvinskiy, A.; Belova, E.; Gamaleya, A.; Tomskiy, A.; Sedov, A.

Авторы: Nezvinskiy A., Belova E., Gamaleya A., Tomskiy A., Sedov A.
Журнал: Parkinsonism and Related Disorders
Том: 122
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 84
Последняя страница: 84
Номер статьи: 106814
DOI: 10.1016/j.parkreldis.2024.106814
Аннотация: Background: Basal ganglia neuronal motor responses could be potential biomarkers for deep brain stimulation (DBS) improvements and are being studied extensively. Taking into account previous research we hypothesized changes of subthalamic (STN) activity during voluntary movements in Parkinson’s disease (PD) patients as follows: the first movement of a series (initiation of a motor program) should lead to alpha activity (7-12 Hz) desynchronisation on a time scale of 2 seconds and each of the rest movements (inside motor program) should desynchronize low-beta activity (12-20 Hz) for a time period of 500 ms.Methods: PD patients were instructed to perform externally-guided motor tests during microelectrode recordings in STN for DBS electrode implantation. The signals from 76 recording sites with prominent rhythmic multiunit spiking activity of 11 akinetic-rigid patients were included in the analysis. Perievent wavelet analysis of rectified neurograms was used to measure dynamics of rhythmic activity during voluntary movements.Results: In our research 55% (42 of 76) of motor tests sites satisfied both suggested activity dynamic patterns, which in our paradigm may be called “responsive”. The group of remaining 45% (34 of 76) motor tests sites doesn’t have any significant difference between oscillatory amplitudes in short time periods before and after movement executions, so they were marked as “not responsive”. We found patients with “responsive” motor tests sites are statistically younger (KW-H=9.78, p<0.01) and have shorter PD duration (KW-H=12.90, p<0.001) than “not responsive” patients but characterised by higher bradykinesia scores (KW-H=10.18, p<0.01).Conclusions: Our findings of specific alpha and low-beta motor-induced desynchronisation could be an important electrophysiological characteristic of PD clinical features. We suppose these characteristics could also be useful for increasing PD patients’ DBS outcome.The study was funded by the Russian Science Foundation (22-15-00344).
Добавил в систему: Гамалея Анна Александровна

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