Phosphatidylglycerol in lipid bilayer. Molecular recognition, conformational transitions, hydrogen bonding and microviscosity

Авторы: Tretiakova D.S., Volynsky P.E., Kobanenko M.K., Alekseeva A.S., Le-Deygen I.M., Vodovozova E.L., Boldyrev I.A.
Журнал: Journal of Molecular Liquids
Том: 411
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 125688
DOI: 10.1016/j.molliq.2024.125688
Аннотация: Phosphatidylglycerol (PG) is an anionic phospholipid, a constituent of biomembranes and an important component of drug delivery formulations and modern vaccines. Its mixtures with phosphatidylcholine (PC) exhibit non-linear properties, which are usually attributed to the molecular immiscibility of PG and PC. Here, using a combination of spectroscopic (FTIR, fluorescence) and computational (quantum chemistry, molecular dynamics) approaches, we show that the nonlinear properties of PG/PC mixtures are caused by hydrogen bonding between PG molecules. The latter are able to change their conformation to either form or break intermolecular hydrogen bonds.
Добавил в систему: Ле-Дейген Ирина Михайловна

№	Имя	Описание	Имя файла	Размер	Добавлен
1.	1-s2.0-S0167732224017471-main.pdf		1-s2.0-S0167732224017471-main.pdf	6,5 МБ	10 августа 2024 [i.m.deygen]

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА