Site-specific degradation of myelin basic protein by the proteasomeстатья
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Дата последнего поиска статьи во внешних источниках: 17 февраля 2021 г.
Аннотация:Multiple sclerosis, a chronic neurodegenerative diseases of an autoimmune nature, is characterized by destruction of the myelin sheaf, which, in turn, leads to degradation of nerve fibers. Among autoantibodies found in blood sera and cerebrospinal fluid of patients
suffering from this pathology, a special place is taken by immunoglobulins against the myelin basic protein(MBP) and its degradation fragments. The details of the process yielding MBP fragments against which antibodies are generated remain largely obscure. Some
researchers believe that the production of peptide epitopes of the MBP functions as a mechanism triggering the neurodegenerative process. Earlier, we and other authors showed that catalytic antibodies and some proteases may be involved in MBP degradation. However, any eukaryotic cell contains the proteasome, a specialized organelle intended for targeted
protein degradation. Proteasomes are highmolecular-weight protein complexes, one of the functions of which is generation of peptides that are then exposed on the cell membrane using histocompatibility molecules. There is every reason to assume that proteasome is directly involved in specific MBP degradation. However, the details of this mechanism remain to be established. In this study, we investigated the characteristics of specific MBP degradation by the proteasome.