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Langmuir monolayers and Langmuir-Blodgett films of pH-sensitive lipidстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 сентября 2017 г.
- Авторы: Khomutov Gennady B., Kim Vitaly P., Potapenkov Kirill V., Parshintsev Alexander A., Soldatov Eugene S., Usmanov Nazym N., Saletsky Alexander M., Sybachin Andrey V., Yaroslavov Alexander A., Migulin Vasiliy A., Taranov Igor V., Cherepenin Vladimir A., Gulyaev Yury V.
- Журнал: Colloids and Surfaces A: Physicochemical and Engineering Aspects
- Том: 532
- Год издания: 2017
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 150
- Последняя страница: 154
- DOI: 10.1016/j.colsurfa.2017.05.070
- Аннотация: A B S T R A C T Colloidal membranous vesicles based on the functionalized liposomes are promising for development of novel efficient systems of controlled and stimuli-triggered drug delivery. In particular, the specific metabolism of cancer cells results in significant acidification in tumors, and thus the corresponding pH value changes can be used as a stimulus for drug release specifically in the tumor areas. pH-sensitive liposomes can be formed via incorporation of special pH-sensitive amphiphilic compounds into the liposomal membrane. Molecules of such compounds undergo a conformational transition caused by certain changes in the pH value of aqueous environment and resulting in corresponding membrane perturbations with rapid leakage of drug content from those liposomes into the areas with corresponding acidity. In the present work the pH-induced changes of Langmuir monolayer compression isotherm and of the structure of corresponding Langmuir-Blodgett films of pH-sensitive synthetic lipid trans-4,5,didodecyloxycarbonyl-trans-2-morpholinocyclohexanol have been observed and studied. The substantial expansion of Langmuir monolayer of that lipid caused by change of the aqueous subphase pH value from 7 to 5 was observed. Corresponding monolayer Langmuir-Blodgett films were deposited on mica substrate surface and studied using AFM technique. The substantial differences in the structure
- Добавил в систему: Хомутов Геннадий Борисович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Langmuir_monolayers_and_Langmuir-Blodgett_films_of_pH-sensi… | 637,3 КБ | 26 сентября 2017 [gbk] | |
| 2. | Полный текст | Langmuir_monolayers_and_Langmuir-Blodgett_films_of_pH-sensi… | 613,3 КБ | 14 августа 2017 [gbk] |