Ca2+ -Dependent Regulatory Activity of Recoverin in Photoreceptor Raft Structures: The Role of Caveolin-1статья
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Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 октября 2014 г.
Аннотация:Recoverin is a Ca2+-binding protein that has been implicated in Ca2+-dependent regulation of desensitization of visual receptor rhodopsin in vertebrate retinal rods. Here we report the increase in Ca2+ sensitivity of recoverin-regulated rhodopsin phosphorylation in photoreceptor membranes enriched in raft structures. The observed effect is mediated by a key protein component of raft structures caveolin-1. The presence of recombinant fragment Phe(81)-Arg(101) of caveolin-1 cytoplasmic domain enhances Ca2+-affinity of recoverin, thus affecting its Ca2+-dependent regulatory activity.