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Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
Аннотация:Two methods of C6-alkylation of hydrocortisone, C6-formylation and direct methylenation, have been studied. It is shown that both methods are effective and can be of practical interest because they can produce 6α-methylhydrocortisone from hydrocortisone with an overall yield of 50–55%. A short and convenient pathway has been found for producing Δ9(11)-6α-methylcorticosteroids used as intermediates in the synthesis of highly active 6α-methyl-9α-halo-substituted hydrocortisone derivatives