Structural Basis and Molecular Mechanisms of Cl– Transmembrane Transport in Cardiomyocytes

Voronina, Y.A.; Karhov, A.M.; Kuzmin, V.S.

Авторы: Voronina Y.A., Karhov A.M., Kuzmin V.S.
Журнал: Moscow University Biological Sciences Bulletin
Том: 79
Номер: 1
Год издания: 2024
Издательство: Allerton Press
Местоположение издательства: New York, N.Y., United States
Первая страница: 17
Последняя страница: 32
Аннотация: The intracellular concentration of chloride anions ([Cl–]i), the equilibrium potential for chlorideanions (ECl), and transmembrane chloride currents (ICl) are significant factors influencing the electrophysiologicalproperties of excitable tissues, including the myocardium. Several types of chloride conductancehave been identified in the heart. In recent years, multiple transmembrane proteins demonstrating chlorideconductance have been identified (CFTR, ClC, TMEM16, and LRRC8), and their expression in cardiactissue has been confirmed. Accumulated data allow for establishing a molecular substrate for some chlorideanion currents (ICl,PKA, ICl,ir, ICl,vol, ICl,swell, ICl,Ca, and Ito2) detected in the heart. Furthermore, the molecularmechanisms regulating [Cl–]i and ECl through chloride cotransporters (KCC and NKCC1) and chloride-bicarbonate exchangers have been established. The variety of structures determining chloride transmembraneconductivity and the complexity of molecular mechanisms regulating chloride homeostasisunderlie the complex effects of activation of chloride transporters in the pacemaker, conduction system,and working myocardium of the heart. This review discusses the structural and biophysical properties as wellas molecular regulation of chloride transporter protein complexes identified in the myocardium. The reviewalso covers the mechanisms by which chloride transmembrane transport influences the bioelectrical activityof cardiomyocytes.
Добавил в систему: Воронина Яна Алексеевна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Structural Basis and Molecular Mechanisms of Cl– Transmembrane Transport in Cardiomyocytesстатья

Прикрепленные файлы