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Enantiomeric-Enriched Ferrocenes: Synthesis, Chiral Resolution, and Mathematic Evaluation of CD-chiral Selector Energies with Ferrocene-Conjugatesстатья
- Авторы: Snegur Lubov V., Borisov Yurii A., Kuzmenko Yuliya V., Davankov Vadim A., Ilyin Mikhail M., Mikhail M.Ilyin Jr, Arhipov Dmitry E., Korlyukov Alexander A., Kiselev Sergey S., Simenel Alexander A.
- Журнал: Molecules
- Том: 22
- Год издания: 2017
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- DOI: 10.3390/molecules22091410
- Аннотация: Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes. X-ray structural data for racemic (R,S)-1N-(3,5-dimethyl pyrazolyl)ethyl ferrocene (1) and its (S)-enantiomer (S)-1 were determined. A series of racemic pyrazolylalkyl ferrocenes was separated into enantiomers by analytical HPLC on - and -cyclodextrins (CD) chiral stationary phases. The quantum chemical calculations of interaction energies of -CD were carried out for both (R)- and (S)-enantiomers. A high correlation between experimental HPLC data and calculated interaction energies values was obtained.
- Добавил в систему: Сименел Александр Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | molecules-22-01410_6hcrlxG.pdf | 2,9 МБ | 28 августа 2017 [alexsim] | |
| 2. | Полный текст | molecules-22-01410.pdf | 2,9 МБ | 28 августа 2017 [alexsim] | |
| 3. | экспертное заключение | exp_zakl2017_Molecules.pdf | 846,8 КБ | 30 июля 2019 [alexsim] |