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Exploring the Therapeutic Potential of Defective Interfering Particles in Reducing the Replication of SARS-CoV-2статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 декабря 2024 г.
- Авторы: Locke M., Grebennikov D., Sazonov I., López-García M., Loguinova M., Meyerhans A., Bocharov G., Molina-París C.
- Журнал: Mathematics
- Том: 12
- Номер: 12
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 1904
- DOI: 10.3390/math12121904
- Аннотация: SARS-CoV-2 still presents a global threat to human health due to the continued emergence of new strains and waning immunity among vaccinated populations. Therefore, it is still relevant toinvestigate potential therapeutics, such as therapeutic interfering particles (TIPs). Mathematical and computational modeling are valuable tools to study viral infection dynamics for predictive analysis.Here, we expand on the previous work on SARS-CoV-2 intra-cellular replication dynamics to includedefective interfering particles (DIPs) as potential therapeutic agents. We formulate a deterministicmodel that describes the replication of wild-type (WT) SARS-CoV-2 virus in the presence of DIPs.Sensitivity analysis of parameters to several model outputs is employed to inform us on thoseparameters to be carefully calibrated from experimental data. We then study the effects of co-infection on WT replication and how DIP dose perturbs the release of WT viral particles. Furthermore, we provide a stochastic formulation of the model that is compared to the deterministic one. These models could be further developed into population-level models or used to guide the development and dose of TIPs.
- Добавил в систему: Бочаров Геннадий Алексеевич