|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Does G-Quadruplexes formation elevate the mutation density in its neighborhoods in the human genome?тезисы доклада
- Авторы: Panova V., Alexeevski A., Zvereva M.
- Сборник: Четырнадцатая международная мультиконференция : Тез. докл
- Тезисы
- Год издания: 2024
- Издательство: ИЦиГ СО РАН
- Местоположение издательства: Новосибирск
- Первая страница: 77
- Последняя страница: 78
- DOI: 10.18699/bgrs2024-1.1-24
- Аннотация: The origin of cancerous processes stems from a diverse range ofmutations found in both somatic cells and germ lines. It is well known that promotermutations in oncogenes play a significant role in the development and progression ofcancer. Three G-quadruplexes (G4s) are formed in vitro from the hTERT gene promoterin a 96-nt DNA sample, even in the presence of single or double specific mutations inG-quadruplex (G4). G4 binds to the MutL component of the MMR repair system. Thisreduces the efficiency of repair of incorrectly paired bases compared to dsDNA.The study aims to test the hypothesis that the formation of G4 leads to an increase in thefrequency of mutations in the neighborhoods of G4. W
- Добавил в систему: Панова Вера Викторовна