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BIOMEDICINE AND BIO-ENGINEERING: SELF-ASSEMBLY OF PROTEINS INDUCED SURFACE OF CARBON POLYMERтезисы доклада
- Авторы: Levchenko V.A., Matveenko V.N.
- Сборник: Book of Abstracts (8th International IUPAC Symposium «Macro- and Supramolecular Architectures and Materials:Multifunctional Materials and Structures» (MAM-17) 6-10 June 2017, Sochi, Russia, ISBN 978-5-7396-0369-2
- Тезисы
- Год издания: 2017
- Место издания: Publishing House of I.M.Sechenov Fitst MSMU Москва
- Первая страница: 196
- Последняя страница: 196
- Аннотация: In the present work effects of high self-organizing and induced epitropic liquid crystal (ELC) orderings of fibers by a surface of carbon polymer with monocrystalline structure are investigated. For studying morphology and self-assembly received ELC structures albumens and fibrinogens, monolayer of proteins were investigated by a method of atom-force microscopy. The self-assembly of ELC layer fibrinogen on a surface of carbon polymer is presented on figure1. Apparently from the figure, structured ELC the fibrinogen layer, formed under influence of the one dimension - ordered monocrystalline carbon, has the changed struc-ture in comparison with what arises on the basis of cleanly intermolecular interaction. Influence of monocrystalline structure of carbon on fibers goes both on borders between sites-cell, and on all surface. And in general, influence of a surface affects structure of an albumin us layer and causes phase transformations into consecutive layers. So, in particular, layer directly adjoining to a surface has gellike close-packed structure. The subsequent ELC layers, less dense. Apparently, the ideal bioactive material should consist of the active centers. Thus all the active centers should be capable grow together with lipid molecules and so to settle down on a surface that growing from them lipid molecules, formed structure as much as possible approached to their natural, i.e. to that which results from intermolecular interactions lipid molecules. The results of this biological test of surface correlate well with physicochemical surface parameters. In conclusion of operation questions on practical application of the nanostructured carbon material in medicine and to development of new biotechnologies on its basis are discussed. The potential applications of this new class of biocompatible material will be highlighted.
- Добавил в систему: Левченко Владимир Анатольевич