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Voltammetric Sensor for Naproxen Enantiomers Based on Paste Electrode Modified with a Chiral Nickel(Ⅱ) Complexстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Zilberg Rufina A., Teres Julia B., Vakulin Ivan V., Bulysheva Elena O., Mukhametdinov Genghiskhan R., Sycheva Maria A., Volkova Anastasia А., Titov Aleksei A., Maleev Victor I., Larionov Vladimir A.
- Журнал: Chirality
- Том: 37
- Номер: 2
- Год издания: 2025
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- Номер статьи: e70025
- DOI: 10.1002/chir.70025
- Аннотация: An enantioselective voltammetric sensor (EVS) based on a paste electrode made of graphitized thermal Carboblack C modified with a Ni(Ⅱ) complex based on (S)-(2-aminomethyl)pyrrolidine and 3,5-di-tert-butylsalicylaldehyde was developed for the recognition and determination of naproxen (Nap) enantiomers. The CBPE@(S)-Ni sensor was found to have good selectivity for Nap enantiomers (ip1S/ip1R= 1.43, ip2S/ip2R = 1.27 for the first/second peaks, respectively). It was found from the linear relationship ip/v1/2 that the rate of diffusion of the electroactive substance to the electrode surface is mainly the limiting stage of the electrode process (the values of the Semerano criterion are 0.47 and 0.66, 0.46 and 0.53 for the first and second peaks of (S)- and (R)-Nap, respectively). The linear concentration range is from 5.0·10-5 to 1·10-3 M and from 2.0·10-4 to 1·10-3 M for (S)- and (R)-Nap, respectively, where the detection limits for the first and second peaks are 5.31·10–7 M and 4.96·10–7 M for (S)-Nap and 7.40·10–7 and 6.79·10–7 for (R)-Nap, while the lower limits of detectable concentrations for the first and second peaks are 1.77·10–6 and 1.65·10-6 M for (S)-Nap and 2.47·10–6 and 2.26·10–6 for (R)-Nap. The sensor demonstrates the highest sensitivity to (S)-Nap (6.44 and 6.90 μA/mM for the first and second peaks). The suggested sensor was successfully tested for the determination of Nap enantiomers in mixtures, in biological fluids, and in medicinal drug forms. The relative standard deviation fluctuates within 2.0–3.9% in urine, 1.6–4.7% in blood plasma, while in pharmaceutical preparations it does not exceed 2.6%.
- Добавил в систему: Ларионов Владимир Анатольевич
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