Место издания:Megaron Athens International Conference Centre, Athens, Greece
Первая страница:782
Последняя страница:782
Аннотация:Modern regenerative medicine has a great need in
resorbable bioactive composite materials for bone
implants. Biodegradable polymers, e.g. polylactide
(PLA), filled with resorbable calcium phosphate (with
the ratio Ca/P ≤ 1.5, e.g. tricalcium phosphate) are
good candidates. Specific macroporous architecture for
osteoconductivity enhancing can be achieved by 3Dprinting
process. In the case of 3D thermal extrusion
technique it is necessary to produce composite
filament (PLA/TCP) with uniform distribution of the
phosphate particles inside PLA prior to printing and to
develop printing regimes1. Another thrust of problem is
structured around hydrophobicity and proteins
adsorption of the vast majority of the polymers and,
therefore, the need in modification of their surface.
The aim of this work is to create bioactive macroporous
composites based on calcium phosphate and
biopolymers, of predetermined complex shape and
enhanced adsorption for bone regeneration.
The tasks of the work include (i) 3D-printing of
macroporous β-TCP/poly(D,L-lactide) for bone
implantation, (ii) modification of the composite
surface, and (iii) albumin protein adsorption test.
