Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Tamarov, K.P.; Osminkina, L.A.; Zinovyev, S.V.; Maximova, K.A.; Kargina, J.V.; Gongalsky, M.B.; Yury, R.; Ahmed, A.; Sviridov, A.P.; Marc, S.; Ivanov, A.V.; Nikiforov, V.N.; Kabashin, A.V.; Timoshenko, V.Y.

Авторы: Tamarov Konstantin P., Osminkina Liubov A., Zinovyev Sergey V., Maximova Ksenia A., Kargina Julia V., Gongalsky Maxim B., Yury Ryabchikov, Ahmed Al-Kattan, Sviridov Andrey P., Marc Sentis, Ivanov Andrey V., Nikiforov Vladimir N., Kabashin Andrei V., Timoshenko Victor Yu
Журнал: Scientific reports
Том: 4
Год издания: 2014
Издательство: Nature Publishing Group
Местоположение издательства: United Kingdom
Первая страница: 7034
DOI: 10.1038/srep07034
Аннотация: Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50 oC under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1–5 W/cm^2). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinomain vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.
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Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapyстатья