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Immune Basis of Therapeutic Effects of Solanum tuberosum L. Polysaccharide on Chronic Peptic Ulcer Healingстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Generalov Evgenii, Laryushkin Denis, Kritskaya Kristina, Kulchenko Nina, Sinitsyn Arkady, Yakovenko Leonid, Generalova Liubov, Belostotsky Nikolay
- Журнал: Pharmaceuticals
- Том: 18
- Номер: 4
- Год издания: 2025
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 502
- Последняя страница: 514
- DOI: 10.3390/ph18040502
- Аннотация: Abstract: Background/Objectives: Polysaccharides are complex molecules with a widerange of biological activities that can be used in various biomedical applications. In thiswork, the antiulcer effect and influence on the level of pro- and anti-inflammatory cytokinesof Solanum tuberosum L. polysaccharide (STP) were studied. Methods: The antiulcer effect ofSTP was studied in the Okabe chronic peptic ulcer model by evaluating the influence of STPon the ulcer index in Wistar rats, comparing it to omeprazole and ranitidine. Dose-effectanalysis was also carried out. The level of pro- and anti-inflammatory cytokines was studiedusing ELISA kits. Results: After treatment in the polysaccharide groups, ulcer healing isobserved in 60–80% of cases, in the omeprazole group in 50%, and in the ranitidine groupin 25%. STP intravenous injections lead to the formation of a more differentiated mucousmembrane; no coarse scar tissue is formed, which is typical for control and comparisondrugs. Glycan causes a significant acceleration of the healing of experimental pepticulcers in rats. STP appears to modulate pro- and anti-inflammatory cytokines. On thefourth and tenth days, a significant decrease in the levels of pro-inflammatory cytokinesIL-1b and IFN-γ was noted in the polysaccharide group compared to the control group,while the level of anti-inflammatory cytokine IL-4 significantly increased. Conclusions:Intravenous administration of STP leads to the restoration of functionality and effectivetissue regeneration. The antiulcer activity of STP is based on the regulation of the pro- andanti-inflammatory balance.
- Добавил в систему: Генералов Евгений Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Полный текст статьи | pharmaceuticals-18-00502.pdf | 4,2 МБ | 2 апреля 2025 [Generalov1992] |
| 2. | Экспертное заключение | Генералов2.jpg | 1,7 МБ | 23 мая 2025 [aps306cellulas] |