In vivo and in vitro development and study of Osteoplastic material based on hydroxyapatite, poly-3-hydroxybutyrate and sodium alginate composition

Gazhva, J.V.; Bonartsev, A.P.; Mukhametshin, R.F.; Zharkova, I.I.; Andreeva, N.V.; Makhina, T.K.; Myshkina, V.L.; Bespalova, A.E.; Zernov, A.L.; Ryabova, V.M.; Ivanova, E.V.; Bonartseva, G.A.; Mironov, A.A.; Shaitan, K.V.; Volkov, A.V.; Muraev, A.A.; Ivanov, S.Y.

Статья опубликована в журнале из списка RSCI Web of Science

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.

Авторы: Gazhva J.V., Bonartsev A.P., Mukhametshin R.F., Zharkova I.I., Andreeva N.V., Makhina T.K., Myshkina V.L., Bespalova A.E., Zernov A.L., Ryabova V.M., Ivanova E.V., Bonartseva G.A., Mironov A.A., Shaitan K.V., Volkov A.V., Muraev A.A., Ivanov S.Y.
Журнал: Современные технологии в медицине
Том: 6
Номер: 1
Год издания: 2014
Первая страница: 6
Последняя страница: 11
Аннотация: The aim of the investigation was to develop a new synthetic material based on poly-3-hydroxybutyrate, sodium alginate and hydroxyapatite in the form of a paste and study in vitro and in vivo its efficiency when repairing bone defects. Materials and Methods. For a paste we used poly-3-hydroxybutyrate (PHB) developed microbiologically, with molecular weight of 52 kDa, hydroxyapatite (HAP) and sodium alginate (Sigma-Aldrich, Germany). Results. A comparative study of implantation results of HAP-PHB and xenogeneic osseous non-demineralized collagen with a defect covered by PHB membrane showed that by day 180 critical bone defect healed completely in a group with HAP-PHB implantation. Despite the fact thatcortical plate formed in a group of patients with implantation of xenogeneic osseous non-demineralized collagen, chronic productive inflammation results in osseous tissue rarefaction and fibrosis formation in interjoist that can have a negative effect on mechanical properties of the bone. Conclusion. The obtained biomaterial based on composite microparticles from PHB and HAP in alginate gel can be used as a filling agent to correct bone tissue defects, since in its structure there are combined solid support elements and a substance able to maintain optimal microenvironment for cell culture. http://www.stm-journal.ru/ru/numbers/2014/1/1034
Добавил в систему: Шайтан Константин Вольдемарович

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In vivo and in vitro development and study of Osteoplastic material based on hydroxyapatite, poly-3-hydroxybutyrate and sodium alginate compositionстатья

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