|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Mechanisms of influence of divalent Mg cation on DNA--Dps complex revealed by molecular modeling methodsстатья
- Авторы: Tereshkina Ksenia Borisovna, Kovalenko Vladislav V., Manuvera Valentin Aleksandrovich, Tereshkin Eduard V., Potokina Victoriya V., Krupyanskii Yurii Fedorovich, Loiko Nataliya G.
- Журнал: Mendeleev Communications
- Том: 35
- Номер: 3
- Год издания: 2025
- Издательство: Russian Academy of Sciences
- Местоположение издательства: Russian Federation
- Первая страница: 307
- Последняя страница: 309
- DOI: 10.71267/mencom.7623
- Аннотация: The destructive effect of divalent cations Mg2+ on the crystal structure of the DNA–Dps complex was explored. It was shown using the classical molecular dynamics methods that this effect resulted from a decrease of interaction between the N-termini of the Dps protein and DNA when the concentration of Mg2+ in the system increases, and important Mg2+ binding sites in the protein and DNA molecules were determined. It is concluded that the preferential interaction of DNA and protein oxygen atoms with the Mg2+ cation leads to the weakening of their mutual bonds and destruction of the DNA–Dps complex.
- Добавил в систему: Терешкина Ксения Борисовна