Porous Osteoplastic CompositeMaterials Based on Alginate–Pectin Complexes and Cation-Substituted Hydroxyapatites

Davydova, G.A.; Fadeeva, I.V.; Trofimchuk, E.S.; Selezneva, I.I.; Mahamadiev, M.T.; Akhmetov, L.I.; Yakovsky, D.S.; Proskurin, V.P.; Fosca, M.; Yankova, V.G.; Rau, J.V.; Saceleanu, V.

Авторы: Davydova Galina A., Fadeeva Inna V., Trofimchuk Elena S., Selezneva Irina I., Mahamadiev Muhriddin T., Akhmetov Lenar I., Yakovsky Daniel S., Proskurin Vadim P., Fosca Marco, Yankova Viktoriya G., Rau Julietta V., Saceleanu Vicentiu
Журнал: Polymers
Том: 17
Номер: 13
Год издания: 2025
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1
Последняя страница: 19
Номер статьи: 1744
DOI: 10.3390/polym17131744
Аннотация: Novel three-dimensional porous composites of alginate–pectin (A/P) with zinc- or manganese-substituted hydroxyapatites (A/P-ZnHA and A/P-MnHA) were synthesized via lyophilization and calcium cross-linking. Powder X-ray diffraction and infrared spectroscopy analyses confirmed single-phase apatite formation (crystallite sizes < 1 µm), with ZnHA exhibiting lattice contraction (*c*-axis: 6.881 Å vs. 6.893 Å for HA). Mechanical testing revealed tunable properties: pristine A/P sponges exhibited an elastic modulus of 4.7 MPa and a tensile strength of 0.10 MPa, reduced by 30–70% by HA incorporation due to increased porosity (pore sizes: 112 ± 18 µm in the case of MnHA vs. 148 ± 23 µm-ZnHA). Swelling capacity increased 2.3–2.8-fold (125–155% vs. 55% for A/P), governed by polysaccharide interactions. Scanning electron microscopy investigation showed microstructural evolution from layered A/P (<100 µm) to tridimensional architectures with embedded mineral particles. The A/P-MnHA composites demonstrated minimal cytotoxicity for the NCTC cells and good viability of dental pulp stem cells, while A/P-ZnHA caused ≈20% metabolic suppression, attributed to hydrolysis-induced acidification. Antibacterial assays highlighted A/P-MnHA′s broad-spectrum efficacy against Gram-positive (Bacillus atrophaeus) and Gram-negative (Pseudomonas protegens) strains, whereas A/P-ZnHA targeted only the Gram-positive strain. The developed composite sponges combine cytocompatibility and antimicrobial activity, potentially advancing osteoplastic materials for bone regeneration and infection control in orthopedic/dental applications.
Добавил в систему: Трофимчук Елена Сергеевна

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Porous Osteoplastic CompositeMaterials Based on Alginate–Pectin Complexes and Cation-Substituted Hydroxyapatitesстатья

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