Аннотация:A brief consideration of the impact on the GMU variety of biological objects at different levels of development shows that the problem of long-stay astronauts beyond the customary and GMF impact GMU on bioregenerative life support system is very significant. Once again, we note that even significant reduction of interplanetary flight will not remove the impact of the GMU on the crew and the ship bioregenerativnye life support systems and bases on the Moon and on Mars