Statistical model of intra-chromosome contact mapsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 ноября 2015 г.
Авторы:
Nazarov L.,
Tamm M.,
Avetisov V.,
Nechaev S.K.
Аннотация:A statistical model describing a fine structure of the intra-chromosome maps obtained by a genome-wide chromosome conformation capture method (Hi-C) is proposed. The model combines hierarchical chain folding with quenched heteropolymer structure of primary chromatin sequences. It is conjectured that observed Hi-C maps are statistical averages over many different ways of hierarchical genome folding. It is shown that the existence of quenched primary structure coupled with hierarchical folding induces full range of features observed in experimental Hi-C maps: hierarchical elements, chess-board intermittency and large-scale compartmentalization