Аннотация:A series of 2-aryl-substituted 1-aminocyclopropylphosphonates
containing an additional remote phosphonate group have been
synthesized starting from readily accessible dimethyl (1R*,2R*)-2-(4-
bromophenyl)-1-formamidocyclopropylphosphonate using cross-coupling
methodology. Different types of palladium-catalyzed reactions for
carbon–carbon and carbon–phosphorus bond formation were realized.
In each case the optimum conditions were found to obtain the desired
products in high yield in both small- and large-scale experiments.