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Foreign Body Reaction to Neural Implants: A Comparative Study of Polymer Toxicity and Tissue Responseстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 октября 2025 г.
- Авторы: Makievskaya C., Brezgunova A., Andrianova N., Kelm E., Solovyova M., Naumova G., Zeinalova A., Gancharova O., Bushkova T., Kozlov D., Putlayev V., Evdokimov P., Petrov A., Lebedev M., Plotnikov E., Popkov V.
- Журнал: Biosensors
- Том: 15
- Номер: 9
- Год издания: 2025
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 599
- Последняя страница: 619
- DOI: 10.3390/bios15090599
- Аннотация: This study investigated the toxicity of ten polymer materials intended for the developmentof invasive neural interfaces improving the treatment of neurological diseases. Most of thematerials for neural implants can cause traumatization of the surrounding tissue, inflam-mation, and foreign body reaction. In this study, in vitro and in vivo toxicity assessmentwas performed for nylon 618 (NY), polycaprolactone (PCL), polyethylene glycol diacrylate(PEGDA), polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), polylactide(PLA), thermoplastic polyurethane (TPU), polypropylene (PP), polyethylene terephthalateglycol (PET-G), and polyimide (PI). The biocompatibility of these ten materials was assessedbased on cell adhesion, growth and cytotoxicity on neural (PC-12) and fibroblast (NRK-49F)cultures. Furthermore, brain tissue responses to the implanted phantom scaffolds wereanalyzed in rats. According to these measurements, PI showed the highest compatibilityfor both cell types. PEGDA exhibited cytotoxic effects, low cell adhesion and the strongestforeign body reaction, including fibrosis and multinucleated cell formation. The otherpolymers showed lower pathological responses which makes them potentially usable forneural interfacing. We conclude that PEGDA appears to be unsuitable for long-term usedue to adverse tissue and cellular reactions, whereas PI, PLA, PDMS and TPU hold promiseas materials for safe and effective neural interface applications.
- Добавил в систему: Брезгунова Анна Александровна
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