|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Studying lipid-mediated regulation of ion channels with dipole modifiers: a 10-year experience. Abstracts of 11th European biophysics congressтезисы доклада
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 29 марта 2018 г.
- Авторы: Ostroumova O.S., Efimova S.S., Zakharova A.A., Malev V.V., Schagina L.V.
- Сборник: Eur. Biophys. J
- Серия: Suppl. 1
- Том: 46
- Тезисы
- Год издания: 2017
- Место издания: Edinburgh, Scotland
- Первая страница: 108
- Аннотация: Here we reviewed our experience of application of lowmolecular weight amphiphiles of dipolar nature, co-called membrane dipole modifiers, to study the influence of lipid environment on ion channels induced by various antimicrobials in lipid bilayers. Different flavonoids, phytoalexins, styryl and xantene dyes, local anesthetics, thyroid hormones, and PDE5 inhibitors were tested as dipole modifiers. At the first stage a detailed analysis of the relationships between the structure of modifying agents and changes in the dipole potential of membrane, its permeability to calcein, lipid domain structure and thermotropic behavior of lipids was carried out. Hereafter we found: 1) a key role of membrane dipole potential in the modulation of channels formed by antimicrobial lipopeptides and peptides: syringomycin E, surfactin, and cecropins; 2) dipolar nature of the gate mechanism providing cooperative opening of syringomycin channels; 3) heterogeneity of population of syringomycin channels which is determined by a mistmach of dipole potential of lipid ordered and disordered domains; 4) dipole modifiers could function as molecular chaperones that ensure the conformational stability of open or close state of lipopeptide and polyene channels.
- Добавил в систему: Ефимова Светлана Сергеевна