Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) with additional protein domain synthesized in E. coli: in vivo osteoinductivity in experimental models on small and large laboratory animalsстатья
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Дата последнего поиска статьи во внешних источниках: 4 января 2018 г.
Аннотация:Recombinant human bone morphogenetic protein-2 with an additional s-tag domain (s-tagBMP-2)
synthesized in E. coli is characterized by higher solubility and activity than the
protein without additional s-tag domain, which increases the yield during purification and
simplifies protein introduction into the osteoplastic materials. The high osteoinductivity of the
demineralized bone matrix with s-tag-BMP-2 was shown on the model of regeneration of
cranial defects of a critical size in mice and on the model of implantation of porous titanium
matrix into defects of femoral and tibial bones in rabbits.